Figure 2 from Targeting the Mitotic Catastrophe Signaling Pathway in Biology Diagrams Keywords: Mitotic catastrophe, Cell death, Senescence, DNA damage, Cancer. Introduction. Back in 1939, Glรผcksmann and Spear first described a fraction of cells in the mitotic stage that instantly declined in response to radiation and did not reappear until several hours following treatment. The term 'mitotic catastrophe' refers either to cell death or a moribund precursor state that is triggered by aberrant mitosis. Mitotic catastrophe can occur either during or after mitosis. 1 Mitotic catastrophe can be induced by a heterogeneous group of stimuli, including chromosome damage and perturbation of the mitotic apparatus. When cells detect DNA damage, they arrest the cell cycle Abstract. Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a
Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses. Igor Roninson attempted to define mitotic catastrophe in morphological terms, namely, as a type of cell death resulting from abnormal mitosis, which usually ends in the formation of large cells
Mitotic catastrophe and cell death induced by depletion of centrosomal ... Biology Diagrams
A cell that has been treated with taxol and had a catastrophic mitosis. The cell has become multinucleated after an unsuccessful mitosis. Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance. Mitotic catastrophe has been observed in response to treatment with a variety of genotoxic agents that have different mechanisms of action (Table 22.1).These data demonstrate that mitotic catastrophe is an important and widely observed mode of death in response to treatment with genotoxic agents [58].It is likely that these cells undergo checkpoint adaptation to enter mitosis with damaged DNA For instance, mitotic catastrophe has been delineated as a type of cell death that: results from abnormal mitosis and is associated with spontaneous premature chromosome condensation and the
